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PRX5 errors

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PRX5 errors - 1.Jun.2015 4:50:43 AM   


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We are getting PRX5 errors in the following log files:
Program Files\Microsoft\Exchange Server\V15\TransportRoles\Logs\FrontEnd\ProtocolLog\SmtpReceive
The errors seem to be random and occur on some incoming on the default frontend connector and also some outgoing messages on the relay connector we use for some applications that do not support Exchange 2013 authentication (Goldmine).
I have applied all the known fixes I have come across i.e. edited hosts files to include the exchange server and fqdn, set specific NIC and DNS ip addresses in External/Internal DNS in ECP gui and also powershell to transportservuce and frontendtransportservice.
Also have register DNS set on the nic adapter.

The error is seemingly random and so proving difficult to solve as we cannot reproduce it on demand.

Anyone else come across this ?
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